Robert B Clarke Selected Research

Notch4 Receptor

4/2019	FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.
1/2010	Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

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Robert B Clarke Research Topics

Disease

60	Breast Neoplasms (Breast Cancer) 01/2022 - 09/2004
48	Neoplasms (Cancer) 01/2022 - 10/2003
8	Neoplasm Metastasis (Metastasis) 11/2019 - 01/2006
7	Noninfiltrating Intraductal Carcinoma (DCIS) 02/2015 - 01/2006
4	Triple Negative Breast Neoplasms 01/2022 - 01/2019
3	Osteosarcoma (Osteogenic Sarcoma) 12/2019 - 12/2013
3	Carcinogenesis 03/2009 - 01/2004
2	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 01/2006
2	Disease Progression 01/2019 - 01/2016
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022
1	Hemorrhage 01/2022
1	Endometrial Neoplasms (Endometrial Cancer) 05/2019
1	Atrophy 01/2018
1	Pathologic Neovascularization 12/2017
1	Insulin Resistance 01/2016
1	Overweight 01/2016
1	Pleural Effusion (Pleural Effusions) 06/2015
1	Brain Neoplasms (Brain Tumor) 06/2015
1	Ascites 06/2015

Drug/Important Bio-Agent (IBA)

11	Estrogens (Estrogen)FDA Link 01/2022 - 09/2004
10	Proteins (Proteins, Gene)FDA Link 11/2019 - 10/2004
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2009
7	Estrogen ReceptorsIBA 11/2020 - 09/2004
6	Estrogen Receptor alphaIBA 05/2014 - 10/2003
5	Tamoxifen FDA LinkGeneric 01/2020 - 01/2011
5	Growth Factor ReceptorsIBA 12/2017 - 01/2006
4	Pharmaceutical PreparationsIBA 05/2020 - 10/2013
4	Messenger RNA (mRNA)IBA 04/2019 - 01/2008
4	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 05/2016 - 04/2007
4	LigandsIBA 02/2014 - 11/2010
4	Notch ReceptorsIBA 01/2013 - 06/2007
3	Phenobarbital (Luminal)FDA Link 01/2022 - 05/2012
3	Phosphotransferases (Kinase)IBA 01/2021 - 10/2004
3	Peptides (Polypeptides)IBA 12/2020 - 07/2013
3	Aldehyde DehydrogenaseIBA 01/2020 - 07/2013
3	Fulvestrant (Faslodex)FDA Link 01/2020 - 09/2015
3	Biological ProductsIBA 02/2016 - 01/2013
3	Hormones (Hormone)IBA 12/2015 - 01/2011
3	Lapatinib (GW572016)FDA Link 01/2014 - 01/2013
3	Interleukin-8 (Interleukin 8)IBA 11/2013 - 01/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 06/2015
2	Progesterone FDA LinkGeneric 01/2022 - 09/2004
2	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 05/2016
2	tyrosine receptor (receptor, tyrosine)IBA 01/2021 - 01/2009
2	Notch4 ReceptorIBA 04/2019 - 01/2010
2	GTP-Binding Proteins (G-Protein)IBA 12/2017 - 12/2017
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 05/2016 - 06/2007
2	Small Interfering RNA (siRNA)IBA 01/2016 - 08/2013
2	LeptinIBA 01/2016 - 08/2009
2	SteroidsIBA 12/2015 - 09/2004
2	EnzymesIBA 09/2015 - 06/2015
2	Telomerase (Telomerase Reverse Transcriptase)IBA 09/2015 - 12/2013
2	Cadherins (E-Cadherin)IBA 02/2014 - 05/2012
2	Gefitinib (Iressa)FDA Link 01/2013 - 04/2007
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2005 - 10/2003
1	ulipristal acetate FDA Link 01/2022
1	Levonorgestrel (Plan B)FDA LinkGeneric 01/2022
1	VitaminsIBA 01/2022
1	Progestins (Progestagens)IBA 01/2022
1	Mifepristone (RU 486)FDA Link 01/2022
1	PlatinumIBA 01/2022
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2021
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2021
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 11/2020
1	sulforaphaneIBA 01/2020
1	EphrinsIBA 12/2019
1	LuciferasesIBA 11/2019
1	Metformin (Glucophage)FDA LinkGeneric 05/2019
1	STAT Transcription FactorsIBA 01/2019
1	p21-Activated KinasesIBA 01/2019
1	Milk Proteins (Milk Protein)IBA 01/2019
1	Caseins (Casein)FDA Link 01/2019
1	Volatile Oils (Essential Oils)IBA 01/2018
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2017
1	Hypoxia-Inducible Factor 1IBA 12/2017
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2017
1	Complement System Proteins (Complement)IBA 12/2016
1	ferric oxide (iron oxide)IBA 02/2016
1	Gemcitabine FDA Link 02/2016
1	Leptin ReceptorsIBA 01/2016
1	Conditioned Culture MediaIBA 01/2016
1	LipidsIBA 01/2016
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 09/2015
1	Mitochondrial DNA (mtDNA)IBA 06/2015
1	Doxycycline (Periostat)FDA LinkGeneric 06/2015
1	Focal Adhesion Protein-Tyrosine KinasesIBA 02/2015
1	CateninsIBA 02/2015
1	Raloxifene Hydrochloride (Evista)FDA Link 09/2014
1	Anastrozole (Arimidex)FDA LinkGeneric 09/2014
1	exemestane (Aromasin)FDA Link 09/2014
1	Laminin (Merosin)IBA 02/2014

Therapy/Procedure

38	Therapeutics 05/2021 - 09/2004
5	Drug Therapy (Chemotherapy) 12/2019 - 01/2008
2	Radiotherapy 02/2015 - 01/2014
2	Chemoprevention 09/2014 - 01/2005
1	Aftercare (After-Treatment) 01/2022
1	Pessaries 01/2018
1	Precision Medicine 01/2017
1	Combined Modality Therapy 02/2016